Anasayfa » NMN (Nikotinamid mononükleotid): Mitokondriler ile Hücresel Gençleşme

NMN (Nikotinamid mononükleotid): Mitokondriler ile Hücresel Gençleşme

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  1. Nadeeshani, H., Ying, J., Zhang, B., Lu, J., et al. (2022). Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns. Journal of Advanced Research, 37, 267–278.
  2. Yamamoto, T., Byun, J., Zhai, P., Ikeda, Y., Oka, S., & Sadoshima, J. (2014). Nicotinamide Mononucleotide, an Intermediate of NAD⁺ Synthesis, Protects the Heart from Ischemia and Reperfusion. PLOS ONE. https://doi.org/10.1371/journal.pone.0098972
  3. PubChem Compound, Summary for CID 14180, Nicotinamide mononucleotide. [cited 2020 Sep 22]. https://pubchem.ncbi.nlm.nih.gov/compound/Nicotinamidemononucleotide
  4. Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., Guarente, L., & Auwerx, J. (2013). The NAD⁺/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell. https://doi.org/10.1016/j.cell.2013.06.016
  5. Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A. (2017). NAD⁺ in Aging: Molecular Mechanisms and Translational Implications. Cell Metabolism, 23(10), 899–916. https://doi.org/10.1016/j.molmed.2017.08.001
  6. Camacho-Pereira, J., Tarragó, M. G., Chini, C. C. S., Nin, V., Escande, C., Warner, G. M., Puranik, A. S., Schoon, R. A., Reid, J. M., Galina, A., & Chini, E. N. (2016). CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metabolism, 24(1), 116–130. https://doi.org/10.1016/j.cmet.2016.05.006
  7. Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., Mercken, E. M., Palmeira, C. M., de Cabo, R., Rolo, A. P., Turner, N., Bell, E. L., & Sinclair, D. A. (2013). Declining NAD⁺ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging. Cell. https://doi.org/10.1016/j.cell.2013.11.037
  8. Cantó, C., Jiang, L. Q., Deshmukh, A. S., Mataki, C., Coste, A., Lagouge, M., Zierath, J. R., & Auwerx, J. (2010). Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle. Cell Metabolism, 11(3), 213–219. https://doi.org/10.1016/j.cmet.2010.02.006
  9. Yu, B., Jing, X., Jia, L., Wang, M., Liu, L., Ping, S., Wang, Y., & Yang, M. (2024). The versatile multi-functional substance NMN: its unique characteristics, metabolic properties, pharmacodynamic effects, clinical trials, and diverse applications. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2024.1436597
  10. Noh, H., Sen Gupta, S., Seshadri, S., & Gonzalez, X. V. (2025). NMN supplementation as a strategy to improve oocyte quality: a systematic review and transcriptomic analysis. Journal of Assisted Reproduction and Genetics. https://doi.org/10.1007/s10815-025-03720-1
  11. Morifuji, M., Higashi, S., Ebihara, S., & Nagata, M. (2024). Ingestion of $\beta$-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study. Volume 46, 4671–4688. https://doi.org/10.1007/s11357-024-01204-1
  12. Kim, M., Seo, J., Sato, T., Fukamizu, Y., Sakurai, T., & Okura, T. (2022). Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients, 14(4), 755. https://doi.org/10.3390/nu14040755
  13. Liao, B., Zhao, Y., Wang, D., Zhang, X., Hao, X., & Hu, M. (2021). Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. Journal of the International Society of Sports Nutrition, 18(54). https://doi.org/10.1186/s12970-021-00442-4
  14. Katayama, T., Uehata, S., Nakashima, N., Nakajo, T., Kitajima, N., Kageyama, M., & Tsuji-Naito, K. (2023). Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial. Scientific Reports, 13. https://doi.org/10.1038/s41598-023-29797-3
  15. Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S.-I., & Klein, S. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science, 372(6547), 1224–1229. https://doi.org/10.1126/science.abe9985
  16. Shade, C. (2020). The Science Behind NMN—A Stable, Reliable NAD⁺ Activator and Anti-Aging Molecule. Integrative Medicine: A Clinician’s Journal, 19(1).

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